Methanol → HCID 131722108, compound

Participants

Reaction Steps

(R)-N5 -(Benzoylaminothiocarbonyl)-N2 -(diphenylacetyl)-(R)-N-[1-(4-methoxyphenyl)ethyl]ornithine amide (2.25 g; 3.6 mmol; from step (a) above), methanol (250 mL), water (250 mL) and K2CO3 (1.49 g; 10.8 mmol) were combined and stirred for 24 h at room temperature. The reaction mixture was then partitioned between EtOAc (250 mL) and brine (250 mL). The EtOAc layer was separated and washed with brine, dried over Na2SO4 and concentrated in vacuo to afford 1.86 g (99%) of the sub-title compound as a white foam.

Provenance & Evidence