Ethylamine → HCID 131722112, compound

Participants

Reaction Steps

A solution of (R)-N5 -(Cbz)-N5 -[methylthio(Cbz-iminomethyl)]-N2 -(diphenylacetyl)-(R)-N-[1-(4-methoxyphenyl)ethyl]ornithine amide(0.5g; 0.63 mmol; from step (d) above) and ethylamine (70% wt. in water; 0.08 mL; 0.94 mmol) in DMF (10 mL) was stirred for 1 h at room temperature. The DMF was removed in vacuo and the residue dissolved in EtOAc. The EtOAc solution was washed with KHSO4 solution, then 0.5 N NaOH solution and then brine, dried over Na2SO4 and concentrated in vacuo to afford 0.33 g of the sub-title compound. The material was used directly in the next step.

Provenance & Evidence