Benzylamine → HCID 131722113, compound

Participants

Reaction Steps

A solution of (R)-N5 -(Cbz)-N5 -[methylthio(Cbz-iminomethyl)]-N2 -(diphenylacetyl)-(R)-N-[1-(4-methoxyphenyl)ethyl]ornithine amide (0.25 g, 0.312 mmol; see Example 35(d) above) and benzylamine (0.05 mL; 0.476 mmol) in DMF (5 mL) was stirred overnight at room temperature. The DMF was removed in vacuo and the residue dissolved in EtOAc. The EtOAc solution was washed with KHSO4 solution, 0.5 N NaOH solution and brine, dried over Na2SO4 and concentrated in vacuo to afford 0.25 g of the sub-title compound. The material was used directly in the next step.

Provenance & Evidence