HCID 47293107, compound → HCID 69740590, compound

HRID 366169Notes

Reaction equation

CN[C:3](=O)[CH2:4]CC1C=CC2C(=CC=CC=2)C=1.[CH3:17][N:18]([C@@H:29]([C:41](=[O:55])[N:42]([CH3:54])[C@@H:43]([C:50](=[O:53])[NH:51][CH3:52])[CH2:44][C:45]1S[CH:47]=[CH:48][CH:49]=1)[CH2:30][C:31]1[CH:40]=[CH:39][C:38]2[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH:32]=1)[C:19](=[O:28])/[CH:20]=[C:21](\[CH3:27])/[CH2:22][C:23]([NH2:26])([CH3:25])[CH3:24].NC(C)(C)CC=CC(N(C)[C@@H](C(=O)N(C)[C@@H](C(=O)NCC(F)(F)F)CC1C=CC=CC=1)CC1C=CC2C(=CC=CC=2)C=1)=O>>[CH3:17][N:18]([C@@H:29]([C:41](=[O:55])[N:42]([CH3:54])[C@@H:43]([C:50](=[O:53])[NH:51][CH3:52])[CH2:44][C:45]1[CH:4]=[CH:3][CH:47]=[CH:48][CH:49]=1)[CH2:30][C:31]1[CH:40]=[CH:39][C:38]2[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH:32]=1)[C:19](=[O:28])/[CH:20]=[C:21](/[CH3:27])\[CH2:22][C:23]([NH2:26])([CH3:25])[CH3:24]

Participants

Reactant 3

HCID 47293107HCID 47293107, compound

HCID 53811515HCID 53811515, compound

HCID 59057086HCID 59057086, compound

Product 1

HCID 69740590HCID 69740590, compound

Procedure

(2R)-2-(N-[{2-Amino-2-methylpropoxy}acetyl]-N-methylamino)-N-((1R)-1-dimethylcarbamoyl)-2-phenylethyl)-N-methyl-3-(2-naphthyl)propionamide: ##STR93## 2E)-5-Amino-5-methyl-N-methyl-N-((1R)-1-(N-methyl-N-((1R)-2-phenyl-1-((2,2,2-trifluoroethyl)carbamoyl)ethyl)carbamoyl)-2-(2-naphthyl)ethyl)hex-2-enamide, and its acetate salt;

Sources & evidence

ORD record: ord-cad9b631309140cb80c4cb6c072264b3
Source dataset: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06127391

Reaction notes

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