Cesium fluoride → 3-(4-Chloro-2-ethylbenzofuran-7-yl)-1-methyl-6-trifluoromethyluracil

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

50 ml of N,N-diethylaniline was added to 1.25 g (3.4 mmol) of 3-[4-chloro-2-(1-methyl-2-propynyloxy)phenyl]-1-methyl-6-trifluoromethyluracil and 1.0 g (6.8 mmol) of cesium fluoride, followed by stirring at 180 to 190° C. for 30 minutes. After completion of the reaction, the reaction mixture was purified directly by silica gel column chromatography to obtain 0.60 g (yield: 50.7%) of the desired product as white crystals. Melting point: 159-160° C.

Herkunft & Nachweise