Acetyl chloride → HCID 23447981, compound

Participants

Reaction Conditions

Reaction Steps

The free amine of compound 64 (100 mg, 0.28 mmol) was dissolved in methylene chloride (5 ml), cooled to 0° C. Triethyl amine (43 μl, 0.31 mmol) was added and then acetyl chloride (22 μl, 0.31 mmol) was added dropwise. After 10 min, the solution was washed with potassium carbonate (10%), dried (K2CO3) and evaporated in vacuo. The residue was purified by chromatography on silica (CH2Cl2 /MeOH/NH3, 95:5:0.5) to give 116 mg of compound 77 (~100 %).

Provenance & Evidence