Ethyl 4-piperidinecarboxylate → Ethyl 1-[6-methyl-4-(3,4-methylenedioxybenzylamino)-thieno-[2,3-d]-pyrimidine-2-yl]-piperidine-4-carboxylate

Participants

Reaction Steps

1.67 g of 2-chloro-6-methyl-4-(3,4-methylenedioxybenzylamino)-thieno-[2,3-d]-pyrimidine and 3 g of ethyl piperidine-4-carboxylate are heated at 130° for 3 hours. After cooling, the residue is dissolved in methylene chloride and the solution is worked up in the customary manner. 0.5 g of ethyl 1-[6-methyl-4-(3,4-methylenedioxybenzylamino)-thieno-[2,3-d]-pyrimidine-2-yl]-piperidine-4-carboxylate is obtained.

Provenance & Evidence