HCID 23289596, compound → HCID 23289424, compound

HRID 366375Notes

Reaction equation

HRID 366375 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:28]=[CH:29][CH:30]=1)[CH2:7][NH:8][C:9]1[C:10]2[C:26]([CH3:27])=[CH:25][S:24][C:11]=2[N:12]=[C:13]([C:15]2[CH:23]=[CH:22][C:18]([C:19]([OH:21])=[O:20])=[CH:17][CH:16]=2)[N:14]=1)([O-])=O>CO.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:28]=[CH:29][CH:30]=1)[CH2:7][NH:8][C:9]1[C:10]2[C:26]([CH3:27])=[CH:25][S:24][C:11]=2[N:12]=[C:13]([C:15]2[CH:16]=[CH:17][C:18]([C:19]([OH:21])=[O:20])=[CH:22][CH:23]=2)[N:14]=1

Participants

4

Reactant 1

HCID 23289596HCID 23289596, compound

Product 1

HCID 23289424HCID 23289424, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A solution of 4-[4-(3-nitrobenzylamino)-5-methyl-thieno-[2,3-d]-pyrimidin-2-yl]-benzoic acid in methanol is hydrogenated in the presence of Raney nickel. The catalyst is filtered off and the solution is concentrated. After recrystallization, 4-[4-(3-amino-benzylamino)-5-methyl-thieno-[2,3-d]-pyrimidin-2-yl]-benzoic acid is obtained.

Workup

  1. filtrationThe catalyst is filtered off
  2. concentrationthe solution is concentrated
  3. customAfter recrystallization

Sources & evidence

ORD record
ord-aac22c287b1b4b9f8b8ce41ab1dbfed5
Source dataset
uspto-grants-2000_10
Patent number
US06130223

Reaction notes

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