Phenol → HCID 70257067, compound

Participants

Reaction Steps

Chloroquinoline derivative (Example 9(C)) (2.0 g, 9.8 mmol), benzylamine (1.2 g, 11.2 mmol) and phenol (4.0 g, 42.6 mmol) were heated at 180° C. for 3 hours. After cooling, 5M sodium hydroxide (50 cm3) was added and the organic components were extracted into dichloromethane, dried (Na2SO4), filtered and the solvent was evaporated. Any remaining volatiles were removed by distillation and the residue was dissolved in hot ethanol, decolorised (charcoal) and recrystallised to give an off-white powder.

Provenance & Evidence