HuagongsheHuagongshe Chemistry Print Report · For research reference only
Heptanedinitrile → 2-Aminocyclohex-1-ene-1-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Heptanedinitrile | HCID 12590 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Aminocyclohex-1-ene-1-carbonitrile | HCID 290175 | — |
Reaction Steps
1,5-Dicyanopentane (Aldrich Chemicals) (25.0 g, 205 mmol), sodium hydride (60% oil dispersion; 8.2 g, 205 mmol) and T.H.F. (150 ml) were heated under reflux for 17 hours. After cooling, water (150 ml) was added and the upper organic layer removed, dried (Na2SO4) filtered and the solvent evaporated. Recrystallisation from hot toluene (80° C.) gave the product as beige crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06130228 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-c54ede75b2ad4a5c849208ca430985ff |
| Source note | uspto-grants-2000_10 |