4-Fluoroaniline → 1-(4'Fluorophenyl) amino-2-cyano-3,4-dihydro-naphthalene

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

4-Fluoro-aniline (Aldrich Chemicals) (1.11 g, 10 mmol) and 2-cyano-3 ,4-dihydro-1 (2H) -naphthalenone (synthesised according to the method of Johnson. W. S. and Shelberg W. E. J. Amer. Chem. Soc., (1945), 67 p.1745.) (91.71 g 10 mmol) were heated together at 150° C. for 1 hour. After cooling, chromatography on silica with chloroform as the eluent followed by Kugelrohr distillation (175° C., 0.2 mmHg) gave the product as pale brown crystals.

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