Benzhydrylpiperazine → HCID 23289343, compound

Participants

Reaction Steps

1-Benzhydryl-piperazine (2.26 g, 8.98 mmol) and 2-[2-(2-bromoethoxy)phenyl]-benzothiazole (0.75 g, 2.24 mmol) were stirred in t-BuOH (20 mL) at about 50° C. under N2 (g) for 24 hours. The mixture was concentrated in vacuo and flash chromatographed on silica (15% acetone/hexanes) to afford 460 mg (41%) of the free base of the product. mp 67-72° C.; LSIMS m/z 506 (MH+).

Provenance & Evidence