HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Chloromethyl)pyridine hydrochloride → 2-Pyridin-3-yl-benzoxazol-6-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Chloromethyl)pyridine hydrochloride | HCID 23394 | — |
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Reactant | 4-Aminobenzene-1,3-diol hydrochloride | HCID 13408822 | — |
| Reactant | 2-(Pyridin-2-yl)-1,3-benzoxazol-6-ol | HCID 135797919 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 2-Pyridin-3-yl-benzoxazol-6-ol | HCID 23289258 | — |
Reaction Steps
2-Pyridin-3-yl-benzoxazol-6-ol was prepared using 4-aminoresorcinol hydrochloride (1.5 g, 9.3 mM), nicotinyl chloride hydrochloride (1.8 g, 10.2 mM), triethylamine (3.0 g, 30.0 mM) and pyridinium-p-toluenesulfonate (PPTS, 800 mg, 3.2 mM) were refluxed in xylenes (50 mL) for about 24 hours as described for 2-pyridin-2-yl-benzoxazol-6-ol; m.p., 176-178° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06130217 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-f7233430c2ad45878479bdb4fa6380eb |
| Source note | uspto-grants-2000_10 |