HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)pyridinium chloride → 3-(5-Pyridin-4-yl-[1,2,4]oxadiazol-3-yl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)pyridinium chloride | HCID 74570 | — |
| Reactant | N,3-dihydroxybenzenecarboximidamide | HCID 54381771 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3-(5-Pyridin-4-yl-[1,2,4]oxadiazol-3-yl)phenol | HCID 23289277 | — |
Reaction Steps
3-(5-Pyridin-4-yl-[1,2,4]oxadiazol-3-yl)phenol was prepared using 3-hydroxybenzamidoxime (3 g, 19.7 mM) and isonicotinyl chloride hydrochloride (3.51 g, 19.6 mM) in pyridine (15 mL) using Preparation 62 to provide 3.65 g of a brown precipitate; m.p., 145-146° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06130217 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-b791f56e48c64422af5653e0f07fa460 |
| Source note | uspto-grants-2000_10 |