関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Allyl bromide | HCID 7841 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Methylbenzo[d]thiazol-7-ol | HCID 23289308 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 7-Allyloxy-2-methyl-benzothiazole | HCID 23289341 | 71.4% |
反応手順
To 7-hydroxy-2-methylbenzothiazole (500 mg, 3.0 mmol) in DMF (3 mL) was added K2CO3 (459 mg, 3.32 mmol) followed by allyl bromide (287 uL, 3.32 mmol). The reaction was heated at about 50° C. for about 4 hours and then poured into water. The aqueous mixture was extracted with EtOAc, the combined organic layers were dried over Na2SO4, and the solvent then removed by rotary evaporation. The resulting oil crystallized on standing to give 7-allyloxy-2-methyl-benzothiazole as yellow crystals (440 mg, 71%); LSIMS m/z 206, m.p. 38-39° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06130217 |
|---|
| 出典データセット | uspto-grants-2000_10 |
|---|
| ORD ID | ord-9206c6099e3a436e85cd088984c81279 |
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| 出典メモ | uspto-grants-2000_10 |
|---|
