Toluene → HCID 70052289, compound

Participants

Role	Name	HCID	Charge
Reactant	Toluene	HCID 1140	—
Reactant	1,1-bis(1,1-dimethylethoxy)-N,N,N-trimethylamine	HCID 547712	—
Reactant	HCID 18727220	HCID 18727220	—
Product	HCID 70052289	HCID 70052289	—

Reaction Steps

N,N-dimethylformamide di-tert-butyl acetal (134 mg, 0.66 mmol) was added to a solution of 2-(R)-{[4-(4-chlorobenzoyl)piperidine-1-sulfonyl]amino}-3-methylbutyric acid (90 mg, 0.22 mmol) in toluene (2.5 ml) at 90° C. The reaction was stired for 3 h and concentrated to give tert-butyl 2-(R)-{[4-(4-chlorobenzoyl)piperidine-1-sulfonyl]amino}-3-methylbutyric acid that was used in the next step with no further purification.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06130220
Source dataset	uspto-grants-2000_10
ORD ID	ord-4036419fce484899a6834f0f8057c236
Source note	uspto-grants-2000_10