HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert.-Butyl N-(cis-1-benzyl-4-methoxypyrrolidin-3-yl)-carbamate → cis-3-(Boc-amino)-4-methoxypyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert.-Butyl N-(cis-1-benzyl-4-methoxypyrrolidin-3-yl)-carbamate | HCID 86744570 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | cis-3-(Boc-amino)-4-methoxypyrrolidine | HCID 86744571 | — |
Reaction Steps
3.5 g (11.4 mmol) of tert.-butyl N-(cis-1-benzyl-4-methoxypyrrolidin-3-yl)-carbamate are hydrogenated in 100 ml of methanol on 2 g of palladium-on-active charcoal (10% of Pd) at 100° C. under 100 bar. The catalyst is filtered off, the filtrate is concentrated and the residue is distilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05416096 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-e7fca8ab410b4da2b101d9eab7ecb9cc |
| Source note | uspto-grants-1995_05 |