HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert.-Butyl N-(trans-1-benzyl-4-methoxypyrrolidin-3yl)carbamate → rac-tert-butyl N-[(3R,4R)-4-methoxypyrrolidin-3-yl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert.-Butyl N-(trans-1-benzyl-4-methoxypyrrolidin-3yl)carbamate | HCID 15069969 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | rac-tert-butyl N-[(3R,4R)-4-methoxypyrrolidin-3-yl]carbamate | HCID 15069971 | — |
Reaction Steps
6.7 g (22 mmol) of tert.-butyl N-(trans-1-benzyl-4-methoxypyrrolidin-3-yl)carbamate are hydrogenated in 150 ml of methanol on 2 g of palladium-on-active charcoal (10% of Pd) under 100 bar at 100° C. The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05416096 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-94462c4fdb6a43548a178c056ea9d5a2 |
| Source note | uspto-grants-1995_05 |