HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → trans-1-Benzyl-4-hydroxy-3-(2-hydroxyethylamino)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | 3-Benzyl-6-oxa-3-azabicyclo(3.1.0)hexane | HCID 9815370 | — |
| Solvent | Water | HCID 962 | — |
| Product | trans-1-Benzyl-4-hydroxy-3-(2-hydroxyethylamino)pyrrolidine | HCID 15069972 | — |
Reaction Steps
40 g (0.22 mol) of 3-benzyl-6-oxa-3-azabicyclo[3.1.0]hexane are heated under reflux with 42 g (0.68 mol) of 2-aminoethanol in 450 ml of water overnight. The solution is extracted once with tert.-butyl methyl ether and the aqueous phase is concentrated. The residue is distilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05416096 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-5e0b272a0f31494d8037c87ba38669d2 |
| Source note | uspto-grants-1995_05 |