6-Benzyl-octahydropyrrolo[3,4-b][1,4]oxazine → Octahydropyrrolo[3,4-b][1,4]oxazine

HRID 36659Notes

Reaction equation

HRID 36659 reaction equation
C([N:8]1[CH2:16][CH:15]2[CH:10]([NH:11][CH2:12][CH2:13][O:14]2)[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH:15]12[CH2:16][NH:8][CH2:9][CH:10]1[NH:11][CH2:12][CH2:13][O:14]2

Participants

4

Reactant 1

HCID 150699806-Benzyl-octahydropyrrolo[3,4-b][1,4]oxazine

Product 1

HCID 15069981Octahydropyrrolo[3,4-b][1,4]oxazine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

7.2 g (33 mmol) of 8-benzyl-2-oxa-5,8-diazabicyclo-[4.3.0]nonane are hydrogenated in 400 ml of methanol with 2.5 g of palladium-on-active charcoal (10% of Pd) under 50 bar at 100° C. The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

Sources & evidence

ORD record
ord-71769ecc5c7245ceb8fe74475d841013
Source dataset
uspto-grants-1995_05
Patent number
US05416096

Reaction notes

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