HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dimethyl 2-(4-bromo-2-nitrophenyl)propanedioate → 4-Bromo-2-nitrophenylacetic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dimethyl 2-(4-bromo-2-nitrophenyl)propanedioate | HCID 15740596 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 4-Bromo-2-nitrophenylacetic Acid | HCID 271551 | 89% |
Reaction Steps
Crude dimethyl 4-bromo-2-nitrophenylmalonate was heated at 110° C. in 40 mL of 6N hydrochloric acid for 24 hours and then cooled. The precipitate was collected by filtration, washed with water and dried to give 5.3 g (89% yield) of 4-bromo-2-nitrophenylacetic acid as an off white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06130238 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-d56218a3c58d42a7a48fa7d7d8c21933 |
| Source note | uspto-grants-2000_10 |