Hydroxyamine hydrochloride → HCID 86193537, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3.3 g of 1-(3-(chloro-difluoro-methoxy)-phenyl)-ethanone, 1.4 g of hydroxylamine hydrochloride and 10 ml of pyridine is stirred at 50° C. for 2 hours. It is then poured into ice-water, extracted with diethyl ether and concentrated using a rotary evaporator, and any pyridine still present is removed azeotropically by means of toluene. Drying under reduced pressure at 60° C. yields 3.75 g of the desired oxime in the form of an oil.

Provenance & Evidence