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tert-butyl (2S)-2-formylpyrrolidine-1-carboxylate → (S)-N-Boc-2-ethynylpyrrolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-butyl (2S)-2-formylpyrrolidine-1-carboxylate | HCID 2734674 | — |
| 反応物 | Diazomethyl-phosphonic-acid-diethylester | HCID 10943016 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | (S)-N-Boc-2-ethynylpyrrolidine | HCID 11030701 | — |
反応手順
(S)-N-Boc-2-Ethynyl-pyrrolidine was prepared according to Method X above by the treatment of (S)-N-Boc-2-formyl-pyrrolidine (470 mg, 2.36 mmol) (Example 87A above) with potassium tert-butoxide (340 mg, 3.07 mmol) and diazomethyl-phosphonic-acid-diethylester (550 mg, 3.07 mmol) (also prepared according to Method X). The product was obtained after silica gel coloumn chromatography with 10% Et2O in hexanes. (Yield 200 mg, 43%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06130239 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-034ed20d26b14257b11ece4674ce6a50 |
| 出典メモ | uspto-grants-2000_10 |