Ethyl Acetate → (s)-2-(n-Boc-n-methylamino)-1-(tert-butyldimethylsilyloxy)-but-3-yne

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Reaction Steps

(S)-2-(N-Boc-N-Methylamino)-1-(-tert-butyldimethylsilyloxy)-but-3-yne was synthesized according to Method Y above by the treatment of (S)-N-Boc-2-amino-1-(-tert-butyldimethylsilyloxy)-but-3-yne (190 mg, 0.64 mmol) (Example 115B) with NaH (18 mg, 0.76 mmol) and Mel (180 mg, 1.27 mmol) in THF (5 mL). The product was obtained after silica gel column chromatography with a 0-10% EtOAc in hexanes gradient. (Yield 190 mg, 95%).

Provenance & Evidence