HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl Peroxide → 3-(Chloromethyl)pyridine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl Peroxide | HCID 7187 | — |
| Reactant | Chlorobenzene | HCID 7964 | — |
| Reactant | 3-Methylpyridine-2-carbonitrile | HCID 819928 | — |
| Product | 3-(Chloromethyl)pyridine-2-carbonitrile | HCID 22747799 | — |
Reaction Steps
The 2-cyano-3-chloromethylpyridine was prepared by chlorination of 2-cyano-3-methylpyridine in chlorobenzene with benzoylperoxide by gradual addition of SO2Cl2 at 80° C. 2-Cyano-3-chloromethylpyridine was obtained in 60-65% conversion. The main impurities are 2-cyano-3-dichloromethylpyridine and unreacted 2-cyano-3-methylpyridine, which do not cause problems in the process of this Preparation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06130229 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-29b9afbe84e3483794e90e9a2064e210 |
| Source note | uspto-grants-2000_10 |