4-Pyridinemethanamine → HCID 23289866, compound

HRID 366795Notes

Reaction equation

HRID 366795 reaction equation
[Cl:1][C:2]1[CH:29]=[CH:28][C:5]2[CH:6]([N:16]3[CH2:21][CH2:20][N:19]([C:22](SC)=[N:23][C:24]#[N:25])[CH2:18][CH2:17]3)[C:7]3[N:15]=[CH:14][CH:13]=[CH:12][C:8]=3[CH2:9][N:10]([CH3:11])[C:4]=2[CH:3]=1.[NH2:30][CH2:31][C:32]1[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=1>>[Cl:1][C:2]1[CH:29]=[CH:28][C:5]2[CH:6]([N:16]3[CH2:21][CH2:20][N:19]([C:22](=[N:30][CH2:31][C:32]4[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=4)[NH:23][C:24]#[N:25])[CH2:18][CH2:17]3)[C:7]3[N:15]=[CH:14][CH:13]=[CH:12][C:8]=3[CH2:9][N:10]([CH3:11])[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 773174-PyridinemethanamineHCID 23289885HCID 23289885, compound

Product 1

HCID 23289866HCID 23289866, compound

Procedure

Methyl 4-(8-chloro-6,11-dihydro-6-methyl-5H-pyrido[3,2-c][1]benzazepin-11-yl)-N-cyano-1-piperazinecarboximidothioate (105 mg) and 4-aminomethyl-pyridine (0.45 ml) were heated at 80° C. in a sealed vial allowing escape of gases. Ice-water was then added, and the resulting tan solid was chromatographed on silica gel to afford the desired product, 107 mg; HRMS, FAB: calcd. 487.2125; found 487.2141.

Workup

  1. customthe resulting tan solid was chromatographed on silica gel

Sources & evidence

ORD record
ord-005165e86aec4b09affdbeffcb55f290
Source dataset
uspto-grants-2000_10
Patent number
US06130229

Reaction notes

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