Sodium Nitrate → HCID 178496714, compound

Participants

Reaction Steps

Deamination of 2'-O-methyladenosine was accomplished by a modified procedure of Iwai et al., Anomeric 9-D-Glucopyranosyl-adenines and 9-D-Glucopyranosyl-hypozanthines, in Synthetic Procedures in Nucleic Acid Chemistry 135-142 (Zorbach & Tipson eds., Interscience Publishers, New York, N.Y., 1965). To a solution of 2'-O-methyladenosine (6.61 g, 23.5 mmol) dissolved in 4.4% aqueous acetic acid was added 13.1 g sodium nitrate (190 mmol). This reaction solution was stirred 24 hours in a foil covered vessel and thereafter evaporated to dryness in vacuo. The product was desalted with Amberlite XAD-4 resin and recrystallized in methanol. FABMS (glycerol) m/z 284 (MH+).

Provenance & Evidence