反应详情

温度

5 °C

To a solution of 60.0 g of the cis-2-butene derivative solution prepared in Example 1 and 250 g of toluene in a round flask reactor, 117.0 g (1.6 mol) of butylamine was added dropwise with stirring for 30 min. at about 5° C. using an ice-bath. After 2 hours of stirring, the crystallized solid was removed by filtration; 42.0 g of 35% HCl (aq) was added to the filtrate, and then excess benzylamine hydrochloride was removed by filtration or extraction. After the solvent was evaporated under reduced pressure, 46.1 g of 1-butyl-3-pyrroline (yield 92.0%) was obtained.

1. stirringAfter 2 hours of stirring
2. customthe crystallized solid was removed by filtration
3. addition42.0 g of 35% HCl (aq) was added to the filtrate
4. customexcess benzylamine hydrochloride was removed by filtration or extraction
5. customAfter the solvent was evaporated under reduced pressure