HCID 15069996, compound → Ethyl 3-(hydroxymethyl)-4-(methylamino)pyrrolidine-1-carboxylate

HRID 36687Notes

Reaction equation

HRID 36687 reaction equation
[CH3:1][N:2]1[O:9][CH2:8][CH:7]2[CH:3]1[CH2:4][N:5]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:6]2>C(O)C.[Pd]>[OH:9][CH2:8][CH:7]1[CH2:6][N:5]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:4][CH:3]1[NH:2][CH3:1]

Participants

4

Reactant 1

HCID 15069996HCID 15069996, compound

Product 1

HCID 15070021Ethyl 3-(hydroxymethyl)-4-(methylamino)pyrrolidine-1-carboxylate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10 g (50 mmol) of ethyl 2-methyl-3-oxa-2,7-diazabicyclo[3.3.0]octane-7-carboxylate (Example H d)) are hydrogenated in 200 ml of ethanol on 3 g of Pd-on-active charcoal (10% of Pd) at 50° C. under 50 bar. The catalyst is filtered off, the filtrate is concentrated and the residue is distilled.

Workup

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

Sources & evidence

ORD record
ord-f07b5c5939194f8e9c893b8e33a9f4c1
Source dataset
uspto-grants-1995_05
Patent number
US05416096

Reaction notes

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