O-Toluidine → 1-Tolyl-3-pyrroline

Participants

Reaction Conditions

Reaction Steps

To a solution of 60.0 g of the cis-2-butene derivative solution prepared in Example 1 and 250 g of toluene in a round flask reactor, 171.7 g (1.6 mol) of toluidine was added dropwise with stirring for 30 min. at 50° C. After 2 hours of stirring, the crystallized solid was removed by filtration; 42.0 g of 35% HCl (aq) was added to the filtrate, and then excess benzylamine hydrochloride was removed by filtration or extraction. After the solvent was evaporated under reduced pressure, 56.8 g of 1-tolyl-3-pyrroline (yield 89.2%) was obtained.

Provenance & Evidence