HCID 15070022, compound → 2-Methyl-4-oxa-2,8-diazabicyclo[4.3.0]nonane

HRID 36688Notes

Reaction equation

HRID 36688 reaction equation
[CH3:1][N:2]1[CH2:10][O:9][CH2:8][CH:7]2[CH:3]1[CH2:4][N:5](C(OCC)=O)[CH2:6]2>O>[CH3:1][N:2]1[CH2:10][O:9][CH2:8][CH:7]2[CH:3]1[CH2:4][NH:5][CH2:6]2

Participants

3

Reactant 1

HCID 15070022HCID 15070022, compound

Product 1

HCID 150700232-Methyl-4-oxa-2,8-diazabicyclo[4.3.0]nonane

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

9 g (42 mmol) of ethyl 2-methyl-4-oxa-2,8-diazabicyclo[4.3.0]nonane-8-carboxylate are heated under reflux with 28 g of Ba(OH)2.8H2O in 280 ml of water overnight. The BaCO3 is filtered off with suction, the filtrate is concentrated and the residue is boiled up with dioxane. The dioxane solution is concentrated and the residue is distilled.

Workup

  1. filtrationThe BaCO3 is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. concentrationThe dioxane solution is concentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-d75db1f10bb84f248269a9d2fe20615a
Source dataset
uspto-grants-1995_05
Patent number
US05416096

Reaction notes

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