HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 2-Methyl-4-oxa-2,8-diazabicyclo[4.3.0]nonane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | (4-(Methylamino)pyrrolidin-3-yl)methanol | HCID 15070024 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 2-Methyl-4-oxa-2,8-diazabicyclo[4.3.0]nonane | HCID 15070023 | — |
Reaction Steps
8.1 g (0.1 mol) of 37% strength formaldehyde solution in 20 ml of n-butanol are added dropwise to 13 g (0.101 mol) of 4-hydroxymethyl-3-methylaminopyrrolidine in 100 ml of n-butanol at room temperature. The mixture is stirred at room temperature overnight and concentrated and the residue is distilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05416096 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-380553e8feab4f418f56f5b551e4b474 |
| Source note | uspto-grants-1995_05 |