HCID 135476520, compound → HCID 178508231, compound

Participants

Reaction Steps

The final stage of the synthesis is accomplished according to the published procedure of Lin et al. (J. Med. Chem. 28:1194-1198, 1985). A solution of 8-(benzyloxy)-2'-deoxyguanosine (0.20 g, 0.54 mmol) in a mixture of methanol (8 mL) and water (8 mL) is hydrogenated over 10% palladium on carbon (0.3 g) at 50 psi and room temperature for 18 hours. The catalyst is removed from filtration and the solvent evaporated to dryness to yield 8-hydroxydeoxyguanosine.

Provenance & Evidence