HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 367016Generated: October 28, 2026
Potassium Hydroxide → Pyrrolo[3,4-b]-1,4-oxazine, octahydro-, trans-
https://huagongshe.com/reaction/367016
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | HCID 57462215 | HCID 57462215 | — |
| Product | Pyrrolo[3,4-b]-1,4-oxazine, octahydro-, trans- | HCID 15069983 | 76.6% |
Reaction Steps
2nd method: A homogenized mixture of (1R,6R)-2-oxa-5,8-diazabicyclo[4.3.0]nonane dihydrobromide and 620 mg (11 mmol) of powdered potassium hydroxide is distilled dry in a bulb tube apparatus at 0.2 mbar and increasing oven temperature to 250° C. 490 mg (76.6% of theory) of (1R,6R)-2-oxa-5,8-diazabicyclo[4.3.0]nonane are obtained as a viscous oil, which slowly crystallizes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06133260 |
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| Source dataset | uspto-grants-2000_10 |
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| ORD ID | ord-1bf839afd8d44c85b110574de38945a8 |
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| Source note | uspto-grants-2000_10 |
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