HuagongsheHuagongshe Chemistry Print Report · For research reference only
6,7-Difluoro-1-(cis-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 6-Fluoro-1-((1R,2S)-2-fluorocyclopropyl)-7-((1S,6S)-2-oxa-5,8-diazabicyclo[4.3.0]nonan-8-yl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6,7-Difluoro-1-(cis-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 13852420 | — |
| Reactant | (4aS,7aS)-octahydropyrrolo[3,4-b][1,4]oxazine | HCID 15069982 | — |
| Product | 6-Fluoro-1-((1R,2S)-2-fluorocyclopropyl)-7-((1S,6S)-2-oxa-5,8-diazabicyclo[4.3.0]nonan-8-yl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid | HCID 56997070 | — |
Reaction Steps
The title compound is prepared analogously to the procedure of Example 8 by reaction of 6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid with (1S,6S)-2-oxa-5,8-diazabicyclo[4.3.0]nonane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06133260 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-fedcefa3f0644476817b8c2c3ecf007b |
| Source note | uspto-grants-2000_10 |