反应详情

5.66 g of 1-(2-chloronicotinoyl)-3-(4-methylphenyl)thiourea and 30 mf of toluene were put in a 100 ml flask. To the flask were then connected a Dean-Stark water separator and a Dimroth condenser. The mixture was then heated under reflux for 4 hours. The reaction mixture was then allowed to cool. The resulting precipitate was collected by filtration, washed with toluene, and then dried under reduced pressure to obtain 4.69 g of 2-(4-methylanilino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one.

1. temperatureThe mixture was then heated
2. temperatureunder reflux for 4 hours
3. temperatureto cool
4. filtrationThe resulting precipitate was collected by filtration
5. washwashed with toluene
6. customdried under reduced pressure