1-Chloro-2-(diethylamine)ethane hydrochloride → HCID 23287630, compound

HRID 367152Notes

Reaction equation

HRID 367152 reaction equation
[NH:1]([C:8]1[S:9][C:10]2[N:18]=[CH:17][CH:16]=[CH:15][C:11]=2[C:12](=[O:14])[N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Li+].Cl.[CH2:22]([N:24]([CH2:28][CH3:29])[CH2:25][CH2:26]Cl)[CH3:23]>>[CH2:22]([N:24]([CH2:28][CH3:29])[CH2:25][CH2:26][N:13]1[C:12](=[O:14])[C:11]2[CH:15]=[CH:16][CH:17]=[N:18][C:10]=2[S:9][C:8]1=[N:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH3:23]

Participants

4

Reactant 3

HCID 133631-Chloro-2-(diethylamine)ethane hydrochlorideHCID 62714Lithium hydrideHCID 122160784H-Pyrido[3,2-e]-1,3-thiazin-4-one, 2-(phenylamino)-

Product 1

HCID 23287630HCID 23287630, compoundYield 47.8%

Procedure

The reaction procedure of Example 11 was followed except that 383 mg of 2-anilino-4H-pyrido[3,2-e]-1,3-thiazin-4-one, 14 mg of lithium hydride and 259 mg of 2-diethylaminoethylchloride hydrochloride were used. As a result, 254 mg of 3-(2-diethylaminoethyl)-2-phenylimino-2,3-dihydro-4H-pyrido[3,2-e]-1,3-thiazin-4-one was obtained.

Workup

  1. customThe reaction procedure of Example 11

Sources & evidence

ORD record
ord-5d9b1947f49f419a966806b2229170cc
Source dataset
uspto-grants-2000_10
Patent number
US06133258

Reaction notes

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