Ammonium thiocyanate → HCID 23287668, compound

HRID 367164Notes

Reaction equation

HRID 367164 reaction equation
Cl[C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[S-:11][C:12]#[N:13].[NH4+].[CH2:15]([NH:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH2:15]([N:22]([C:12]1[S:11][C:2]2[N:10]=[CH:9][CH:8]=[CH:7][C:3]=2[C:4](=[O:5])[N:13]=1)[C:23]1[CH:28]=[CH:27][C:26]([C:29]([F:30])([F:31])[F:32])=[CH:25][CH:24]=1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 3

HCID 15666Ammonium thiocyanateHCID 27745412-Chloronicotinoyl chlorideHCID 15502218HCID 15502218, compound

Product 1

HCID 23287668HCID 23287668, compoundYield 56.5%

Procedure

The reaction procedure of Example 57 was followed except that 190 mg of 2-chloronicotinoyl chloride, 83 mg of ammonium thiocyanate and 271 mg of 4-(benzylamino)benzotrifluoride were used. As a result, 252 mg of 2-[N-benzyl-N-(4-trifluoromethylphenyl)amino]-4H-pyrido[3,2-e]-1,3-thiazin-4-one was obtained.

Workup

  1. customThe reaction procedure of Example 57

Sources & evidence

ORD record
ord-544399c8c85044d787d93ee90d136b44
Source dataset
uspto-grants-2000_10
Patent number
US06133258

Reaction notes

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