HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium thiocyanate → Ethyl 4-[methyl(4-oxo-4H-pyrido[3,2-e]-1,3-thiazin-2-yl)amino]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium thiocyanate | HCID 15666 | — |
| Reactant | ethyl 4-(methylamino)benzoate | HCID 319832 | — |
| Reactant | 2-Chloronicotinoyl chloride | HCID 2774541 | — |
| Product | Ethyl 4-[methyl(4-oxo-4H-pyrido[3,2-e]-1,3-thiazin-2-yl)amino]benzoate | HCID 23287619 | 88.8% |
Reaction Steps
The reaction procedure of Example 57 was followed except that 162 mg of 2-chloronicotinoyl chloride, 72 mg of ammonium thiocyanate and 169 mg of ethyl 4-(methylamino)benzoate were used. As a result, 279 mg of ethyl 4-[N-methyl-N-(4-oxo-4H-pyrido[3,2-e]-1,3-thiazin-2-yl)amino]benzoate was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06133258 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-10050d6ccbfc457a835e090e6993c95b |
| Source note | uspto-grants-2000_10 |