Ammonium thiocyanate → 2-(N-methyl-N-(2-methylphenyl)amino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one

Participants

Reaction Steps

The reaction procedure of Example 57 was followed except that 1.613 mg (10.24 mmol) of 2-chloronicotinic acid, 15 ml of thionyl chloride, two droplets of DMF, 780 mg of ammonium thiocyanate, 15 ml of acetone, 1.21 g of N-methyl-o-toluidine and 10 ml of acetone were used. The resulting crude product was then recrystallized from ethanol to obtain 2.28 g of 2-(N-methyl-N-(2-methylphenyl)amino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one.

Provenance & Evidence