1,2,3,4-Tetrahydroisoquinoline → HCID 23287749, compound

Participants

Reaction Steps

The reaction procedure of Example 57 was followed except that 1.718 g (10.90 mmol) of 2-chloronicotinic acid, 15 ml of thionyl chloride, two droplets of DMF, 872 mg of ammonium thiocyanate, 15 ml of acetone, 1.52 g of 1,2,3,4-tetrahydroisoquinoline and 15 ml of acetone were used. The resulting crude product was then recrystallized from ethanol to obtain 1.58 g of 2-(1,2,3,4-tetrahydroisoquinolin-2-yl)-4H-pyrido[3,2-e]-1,3-thiazin-4-one.

Provenance & Evidence