Dimethylformamide → HCID 23287581, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1.104 g (3.77 mmol) of 1-(2-chloronicotinoyl)-3-(3-pyridyl)thiourea and 10 ml of DMF was heated over a 140° C. oil bath. The mixture was stirred for 1 hour. The reaction mixture was allowed to cool, and then diluted with THF. The resulting crystal was collected by filtration, washed with THF, and then dried under reduced pressure to obtain to obtain 759 mg of 2-(3-pyridylamino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one hydrochloride.

Provenance & Evidence