HCID 23287727, compound → HCID 23287731, compound

Participants

Reaction Steps

120 mg of 2-(4-hydroxypiperidino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one (compound of Example 108), 250 mg of crushed molecular sieve (3A) and 7.2 ml of methylene chloride were mixed. To the mixture was then added 196 mg of pyridinium chlorochromate (PCC). The mixture was then stirred at room temperature for 1.5 hours. The reaction mixture was immediately filtered through 10 g of a silica gel layer, and then eluted with a 50:1:0.1 mixture of chloroform, methanol and aqueous ammonia. The resulting filtrate and elute were concentrated, subjected to separation through silica gel column chromatography (eluant: 50:1:0.1 mixture of chloroform, methanol and aqueous ammonia), and then washed with hot acetonitrile to obtain 72 mg of 2-(4-oxo-1-piperidinyl)-4H-pyrido[3,2-e]-1,3-thiazin-4-one.

Provenance & Evidence