Sodium Hydroxide → HCID 23287656, compound

HRID 367207Notes

Reaction equation

HRID 367207 reaction equation
[CH3:1][N:2]([C:14]1[CH:24]=[CH:23][C:17]([C:18]([O:20]CC)=[O:19])=[CH:16][CH:15]=1)[C:3]1[S:4][C:5]2[N:13]=[CH:12][CH:11]=[CH:10][C:6]=2[C:7](=[O:9])[N:8]=1.[OH-].[Na+]>C(O)C>[CH3:1][N:2]([C:14]1[CH:24]=[CH:23][C:17]([C:18]([OH:20])=[O:19])=[CH:16][CH:15]=1)[C:3]1[S:4][C:5]2[N:13]=[CH:12][CH:11]=[CH:10][C:6]=2[C:7](=[O:9])[N:8]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 23287619Ethyl 4-[methyl(4-oxo-4H-pyrido[3,2-e]-1,3-thiazin-2-yl)amino]benzoate

Product 1

HCID 23287656HCID 23287656, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The reaction procedure of Example 116 was followed except that 70 mg g of ethyl 4-[N-methyl-N-(4-oxo-4H-pyrido[3,2-e]-1,3-thiazin-2-yl)amino]benzoate, 0.9 ml of ethanol and 0.9 ml of a 0.25 N aqueous solution of sodium hydroxide were used. As a result, 61 mg of 4-(N-methyl-N-(4-oxo-4H-pyrido[3,2-e]-1,3-thiazin-2-yl)amino]benzoic acid was obtained.

Workup

  1. customThe reaction procedure of Example 116

Sources & evidence

ORD record
ord-9e68193823f74e2a93b037a21466a820
Source dataset
uspto-grants-2000_10
Patent number
US06133258

Reaction notes

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