HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium thiocyanate → 2-[N-methyl-N-(quinolin-6-yl)amino]-4H-pyrido[3,2-e]-1,3-thiazin-4-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium thiocyanate | HCID 15666 | — |
| Reactant | 2-Chloronicotinoyl chloride | HCID 2774541 | — |
| Reactant | N-methylquinolin-6-amine | HCID 12765505 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 2-[N-methyl-N-(quinolin-6-yl)amino]-4H-pyrido[3,2-e]-1,3-thiazin-4-one hydrochloride | HCID 23287634 | — |
Reaction Steps
The reaction procedure of Example 102 was followed except that 334 mg of 2-chloronicotinoyl chloride, 145 mg of ammonium thiocyanate, 300 m of 6-(methylamino)quinoline and 7 ml of acetone were used. The resulting crude product was then washed with hot ethanol to obtain 324 mg of 2-[N-methyl-N-(quinolin-6-yl)amino]-4H-pyrido[3,2-e]-1,3-thiazin-4-one hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06133258 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-0c8b006b952a46e5bb3a57ee981f374a |
| Source note | uspto-grants-2000_10 |