1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- → Phthalimide

Participants

Reaction Steps

The reaction and processing procedure of Example 127 was followed except that 30 mg (3.8 mmol) of lithium hydride, 17 ml of DMF, 800 mg (2.8 mmol) of 2-(4-chloroanilino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one and 1.12 g of N-(2-bromoethyl)-phthalimide were used and post-treatment was carried out. The resulting residue was then purified through silica gel column chromatography (eluant: 1/2 mixture of ethyl acetate and normal hexane) to obtain 883 mg of 2-[2-[2-(4-chlorophenyl)imino]-4-oxo-2,3-dihydro-4H-pyrido[3,2-e]-1,3-thiazin-3-yl]ethyl]isoindol-1,3-dione.

Provenance & Evidence