Trifluoroacetic acid → HCID 53767324, compound

Participants

Reaction Steps

(S)-4-[2-(tert-Butoxycarbonylamino)-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylbutyramide (396 mg) was dissolved in 5 ml of methylene chloride, a solution of 5 ml of trifluoroacetic acid in 5 ml of methylene chloride was added to the solution with stirring under ice-cooling, and the mixture was stirred for 15 minutes and then subjected to 15 minutes of reaction at room temperature. The reaction solution was concentrated under reduced pressure, methylene chloride, water and sodium bicarbonate were added to the residue, and the mixture was stirred at room temperature for 30 minutes. The organic layer was separated and dried over anhydrous magnesium sulfate. By evaporating the solvent under reduced pressure, 263 mg of (S)-4-(2-amino-1,2,3,4-tetrahydronaphthalen-7-yloxy)-N,N-dimethylbutyramide was obtained in an oily form.

Provenance & Evidence