反应详情

Methyl 2-[2-benzyloxy-5-(2-methyl-1,3-dioxolan-2-yl)phenyl]acetate (9.0 g) was dissolved in 130 ml of diethyl ether, 1.0 g of lithium aluminum hydride in small portions was added to the solution with stirring under ice-cooling, and the mixture was subjected to 1 hour of reaction. Water was added in small portions to the reaction solution with stirring under ice-cooling, and the formed precipitates were removed by filtration. By concentrating the resulting filtrate under reduced pressure, 9.0 g of 2-[2-benzyloxy-5-(2-methyl-1,3-dioxolan-2-yl)phenyl]ethanol was obtained in an oily form.

1. temperaturecooling
2. customthe mixture was subjected to 1 hour of reaction
3. stirringwith stirring under ice-
4. temperaturecooling
5. customthe formed precipitates
6. customwere removed by filtration
7. concentrationBy concentrating the resulting filtrate under reduced pressure