反应详情

Ethyl 2-[4-benzyloxy-3-(2-benzyloxyethyl)phenyl]-2-hydroxyacetate (39.7 g) was suspended in 40 ml of ethanol, 57 ml of 2 N aqueous sodium hydroxide solution was added to the suspension with stirring under ice-cooling, and the mixture was subjected to 1 hour of reaction at room temperature. Then, 57 ml of 2 N aqueous sulfuric acid solution was added to the reaction solution with stirring under ice-cooling, and the mixture was extracted with ethyl acetate. The extract was washed with water and then dried over anhydrous magnesium sulfate. Thereafter, the solvent was evaporated under reduced pressure to give 35.1 g of 2-[4-benzyloxy-3-(2-benzyloxyethyl)phenyl]-2-hydroxyacetic acid in an oily form.

1. temperaturecooling
2. customthe mixture was subjected to 1 hour of reaction at room temperature
3. stirringwith stirring under ice-
4. temperaturecooling
5. extractionthe mixture was extracted with ethyl acetate
6. washThe extract was washed with water
7. dry with materialdried over anhydrous magnesium sulfate
8. customThereafter, the solvent was evaporated under reduced pressure