HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → (-)-2-[(2S)-2-[[(2R)-2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)ethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | D-Tartaric acid | HCID 439655 | — |
| Reactant | L-Tartaric acid | HCID 444305 | — |
| Reactant | (-)-1-[2-[(2S)-2-[[(2R)-2-hydroxy-2-(4-hydroxy-3hydroxymethylphenyl)ethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]acetyl]pyrrolidine | HCID 15485660 | — |
| Product | (-)-2-[(2S)-2-[[(2R)-2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)ethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide | HCID 9811600 | — |
Reaction Steps
Using (-)-1-[2-[(2S)-2-[[(2R)-2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)ethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]acetyl]pyrrolidine (Compound 7) and sulfuric acid, L-tartaric acid or D-tartaric acid, the following salts were obtained in the same manner as that described in Example 7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06133266 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-df0d7820dedd4d0298451668fa9d5686 |
| Source note | uspto-grants-2000_10 |